Beauvericin Potentiates Azole Activity via Inhibition of Multidrug Efflux, Blocks Candida albicans Morphogenesis, and Is Effluxed via Yor1 and Circuitry Controlled by Zcf29
نویسندگان
چکیده
منابع مشابه
Regulatory circuitry governing morphogenesis in Saccharomyces cerevisiae and Candida albicans
4294 Cell Cycle Volume 11 issue 23 A common hallmark of many fungal species is the capacity to undergo cellular morphogenesis programs, which, for fungal pathogens, play critical roles in sexual reproduction, nutrient acquisition and virulence. Fungal morphogenesis comprises a diversity of processes, ranging from spore germination and branching in filamentous fungi such as the pathogen Aspergil...
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OBJECTIVES The purpose of this study was to investigate whether mechanisms of azole resistance in Candida albicans contribute to reduced micafungin activity in vitro. METHODS MICs were determined for a collection of strains with well-characterized mechanisms of azole resistance obtained from systemic, oral and vaginal infections. This collection of strains includes those with resistance-assoc...
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Antifungal azoles (e.g., fluconazole) are widely used for prophylaxis or treatment of Candida albicans infections in immunocompromised individuals, such as those with AIDS. These individuals are frequently treated with a variety of additional antimicrobial agents. Potential interactions between three azoles and 16 unrelated drugs (antiviral, antibacterial, antifungal, and antiprotozoal agents) ...
متن کاملMorphogenesis in Candida albicans.
Candida albicans is termed a dimorphic fungus because it proliferates in either a yeast form or a hyphal form. The switch between these forms is the result of a complex interplay of external and internal factors and is coordinated in part by polarity-regulating proteins that are conserved among eukaryotic cells. However, yeast and hyphal cells are not the only morphological states of C. albican...
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1 Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi110067, India; 2 International Centre for Genetic Engineering and Biotechnology, New Delhi-110067, India; 3 School of Physical Sciences, Jawaharlal Nehru University, New Delhi-110067, India; 4 School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi-110067, India; 5 Publ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2016
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.01959-16